职称：教授
学位：博士
政治面貌：中共党员
邮箱：tujiagang@mail.hzau.edu.cn
研究方向：鱼类病毒致病机理及免疫防控
教育经历
2002.09-2006.06 皇冠welcome体育登录入口生命科学技术学院，获学士学位
2006.09-2011.12 皇冠welcome体育登录入口动物科学技术学院动物医学院，获博士学位
主要职历
2012.09-2015.05 美国德州大学休斯敦健康科学中心, 博士后
2015.10-2017.09 皇冠welcome体育登录入口 皇冠welcome体育登录入口，师资博士后
2017.10-2023.10 皇冠welcome体育登录入口 皇冠welcome体育登录入口，副教授
2023.11-至今 皇冠welcome体育登录入口 皇冠welcome体育登录入口，教授
科研成果
主持科研项目
1. 国家重点研发计划子课题，大宗淡水鱼类出血病的发生机制及传播阻断技术研究，2023.12-2027.12，在研
2. 国家自然科学基金面上项目，聚合酶复合物L-P通过泛素化修饰调节乌鳢水泡病毒增殖和毒力的分子机制研究，2022.01-2025.12，在研
3. 国家自然科学基金面上项目，Leader RNA与N蛋白互作调节乌鳢水泡病毒增殖的分子机制研究，2020.01-2023.12，已结题
4. 国家自然科学基金青年项目，MiR-214在乌鳢水泡病毒感染SSN-1细胞中的调控机制研究，2017.01-2019.12，已结题
5. 横向项目，鱼类病毒病疫苗和药物研发，2020.01-2022.12，已结题
6. 横向项目，乌鳢水泡病毒减毒疫苗的研制，2019.01-2019.12，已结题
7. 中央高校科研业务费，乌鳢水泡病毒P蛋白异构体P3的功能研究， 2018.01-2020.12，已结题
8. 中国博士后科学基金，乌鳢水泡病毒调控宿主microRNA的机制研究， 2017.01-2018.12，已结题
代表性论文
1. Ningyan Jiang, Hongyan Zhao, Xiangmou Qin, Yong-An Zhang*, Jiagang Tu*. Siah2- and LRSAM1-mediated K63-linked ubiquitination of snakehead vesiculovirus nucleoprotein facilitates viral replication. Journal of Virology, 2024, 98(7): e0020224.
2. Xiangmou Qin, Ningyan Jiang, Jingjing Zhu, Yong-An Zhang*, Jiagang Tu*. Snakehead vesiculovirus hijacks SH3RF1 for replication via mediating K63-linked ubiquitination at K264 of the phosphoprotein. International Journal of Biological Macromolecules, 2024, 255:128201.
3. Xiangmou Qin, Yong-An Zhang*, Jiagang Tu*. P38MAPK- and GSK3-mediated phosphorylation of snakehead vesiculovirus phosphoprotein at threonine 160 facilitates viral replication. Journal of Virology, 2023, 97(5): e0040423.
4. An-Qi Liu, Xiangmou Qin, Hui Wu, Hao Feng, Yong-An Zhang*, Jiagang Tu*. hnRNPA1 impedes snakehead vesiculovirus replication via competitively disrupting viral phosphoprotein-nucleoprotein interaction and degrading viral phosphoprotein. Virulence, 2023, 14(1): 2196847.
5. Congran Bei#, Chu Zhang#, Hui Wu, Hao Feng, Yong-An Zhang, Jiagang Tu*. DDX3X is hijacked by snakehead vesiculovirus phosphoprotein to facilitate virus replication via stabilization of the phosphoprotein. Journal of Virology, 2023, 97(2): e0003523.
6. Chi Zhang, An-Qi Liu, Chu Zhang, Lan-Hao Liu, Jianguo Su, Yong-An Zhang*, Jiagang Tu*. MicroRNA miR-722 inhibits cyprinid herpesvirus 3 replication via targeting the viral immune evasion protein ORF89, which negatively regulates IFN by degrading IRF3. Journal of Immunology, 2022, 209(10):1918-1929.
7. Lin Jiang, An-Qi Liu, Chu Zhang, Yong-An Zhang*, Jiagang Tu*. Hsp90 regulates GCRV-II proliferation by interacting with VP35 as its receptor and chaperone. Journal of Virology, 2022, 96(19): e0117522.
8. Yanwei Zhang, Yong-An Zhang*, Jiagang Tu*. Hsp90 is required for snakehead vesiculovirus replication via stabilization of the viral L protein. Journal of Virology, 2021, 95(16): e0059421.
9. Xiangmou Qin#, Shuangshuang Feng#, Yanwei Zhang, Jianguo Su, Li Lin, Yong-An Zhang*, Jiagang Tu*. Leader RNA regulates snakehead vesiculovirus replication via interacting with viral nucleoprotein. RNA Biology, 2021, 18(4): 537-546.
10. Chi Zhang, Jiagang Tu*, Yong-An Zhang*. MicroRNA regulation of viral replication in teleost fish: a review. Reviews in Aquaculture, 2021, 13(3): 1367-1378.
备注
研究方向：围绕草鱼出血病、乌鳢水泡病毒病、加州鲈虹彩病毒病开展致病机理及免疫防控研究。欢迎感兴趣的同学加盟！
